26 November 1999 Oxford Journal

I CAROTENOIDI  CANCEROGENI AUMENTANO LA LORO TOSSICITA' PORTANDO IL CANCRO POLMONARE FRA I BEVITORI DI ALCOOL, MA NON FRA I NON BEVITORI  E' QUANTO RISULTA DA UNO STUDIO SCIENTIFICO (National Cancer Institute U.S.A., e altri ricercatori)   EFFETTUATO SU UN GRUPPO DI MINATORI. 

Da Oxford Journal:Abstract

SERUM CAROTENOIDS ARE ASSOCIATED WITH INCREASED LUNG CANCER RISK AMONG ALCOHOL DRINKERS, BUT NOT AMONG NON-DRINKERS IN A COHORT OF TIN MINERS

Duminda Ratnasinghe ^*, Michele R. Forman, Joseph A. Tangrea, Youlin Qiao¹, Shu-Xiang Yao², Elaine W. Gunter³, Michael J. Barrett⁴, Carol A. Giffen⁴, Yener Erozan⁵, Melvyn S. Tockman⁶ and Philip R. Taylor

Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, MD, USA,
¹ CICAMS, Beijing,
² Yunnan Tin Corporation, Gejiu, Yunnan Province, People's Republic of China,
³ NHANES Laboratory of Biochemical Analyses at the Centers for Disease Prevention and Control, Atlanta, GA,
⁴ Information Management Services, Inc., Silver Spring MD,
⁵ Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD and
⁶ H. Lee Moffit Cancer Center and Research Institute, Tampa, FL, USA

(Received 26 November 1999; in revised form 7 February 2000; accepted 14 February 2000)

To examine the association between pre-diagnostic serum carotenoid levels and lung cancer risk and the effects of alcohol intake on the carotenoid–lung cancer relationship, we conducted a case-control study in an occupational cohort from the Yunnan Tin Corporation in China. During 6 years of follow-up, 339 cases of confirmed lung cancer were diagnosed. Among these cases, those who donated pre-diagnostic blood (n = 108) were eligible for this study. For each case, two individuals alive and free of cancer at the time of case diagnosis, matched on age, sex, and date of blood collection, were selected as controls. Serum ß-carotene (odds ratios (ORs) for tertiles: 1, 1.3, 2.0) and ß-cryptoxanthin (ORs for tertiles: 1, 1.8, 2.9) levels were positively associated with lung cancer risk after adjustment for tobacco use and radon exposure. Among alcohol drinkers, higher serum carotenoid levels were significantly associated with increased lung cancer risk (a-carotene OR 2.2, 95% confidence interval (CI) 1.1–4.4, ß-carotene OR 7.6, 95% CI 3.1–18.6, lutein/zeaxanthin OR 2.3, 95% CI 1.2–6.6 and ß-cryptoxanthin OR 7.6, 95% CI 2.7–21.5). Conversely, risk estimates among non-drinkers suggest a possible protective association for higher carotenoid levels.

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